Monica Payne was last seen around 11 p.m. Sunday night near North 70th Street and Thurston Avenue, two blocks north of Silver Spring Drive.
Police said Payne stands 5 feet 10 inches tall and weighs around 140 pounds. She has brown eyes, black hair and is cognitively delayed.
She was last seen wearing a lavender coat with white fur on the collar, a black scarf, jeans and black tennis shoes.
Anyone with information on Payne's whereabouts should call police at 414-935-7405.